Applications for Transition-Metal Chemistry in Contrast-Enhanced Magnetic Resonance Imaging.
Rocío Uzal-Varela, Aurora Rodríguez-Rodríguez, Miguel Martínez-Calvo, Fabio Carniato, Daniela Lalli, David Esteban-Gómez, Isabel Brandariz, Paulo Pérez-Lourido, Mauro Botta, Carlos Platas-Iglesias.Co(II) Macrocyclic Complexes Appended with Fluorophores as paraCEST and cellCEST Agents. Complexation of Mn(II) by Rigid Pyclen Diacetates: Equilibrium, Kinetic, Relaxometric, Density Functional Theory, and Superoxide Dismutase Activity Studies. Zoltán Garda, Enikő Molnár, Nadège Hamon, José Luis Barriada, David Esteban-Gómez, Balázs Váradi, Viktória Nagy, Kristof Pota, Ferenc Krisztián Kálmán, Imre Tóth, Norbert Lihi, Carlos Platas-Iglesias, Éva Tóth, Raphaël Tripier, Gyula Tircsó.Mn2+ Complexes with Pyclen-Based Derivatives as Contrast Agents for Magnetic Resonance Imaging: Synthesis and Relaxometry Characterization. Marie Devreux, Céline Henoumont, Fabienne Dioury, Sébastien Boutry, Olivier Vacher, Luce Vander Elst, Marc Port, Robert N.Dinuclear Fe(III) Hydroxypropyl-Appended Macrocyclic Complexes as MRI Probes. A Macrocyclic Ligand Framework That Improves Both the Stability and T1-Weighted MRI Response of Quinol-Containing H2O2 Sensors. Beyers, Ivana Ivanović-Burmazović, Christian R. Sana Karbalaei, Erik Knecht, Alicja Franke, Achim Zahl, Alexander C.ACS Applied Materials & Interfaces 2021, 13 Paramagnetic Mn8Fe4-co-Polystyrene Nanobeads as a Potential T1–T2 Multimodal Magnetic Resonance Imaging Contrast Agent with In Vivo Studies. Vidumin Dahanayake, Trevor Lyons, Brendan Kerwin, Olga Rodriguez, Christopher Albanese, Erika Parasido, Yichien Lee, Edward Van Keuren, Luxi Li, Evan Maxey, Tatjana Paunesku, Gayle Woloschak, Sarah L.Journal of the American Chemical Society 2021, 143 Characterization of Americium and Curium Complexes with the Protein Lanmodulin: A Potential Macromolecular Mechanism for Actinide Mobility in the Environment. Metal−Organic Polyhedron with Four Fe(III) Centers Producing Enhanced T1 Magnetic Resonance Imaging Contrast in Tumors. 55/52Mn2+ Complexes with a Bispidine-Phosphonate Ligand: High Kinetic Inertness for Imaging Applications. Maryame Sy, Daouda Ndiaye, Isidro da Silva, Sara Lacerda, Loïc J.Thermodynamic Stability of Mn(II) Complexes with Aminocarboxylate Ligands Analyzed Using Structural Descriptors. Rocío Uzal-Varela, Francisco Pérez-Fernández, Laura Valencia, Aurora Rodríguez-Rodríguez, Carlos Platas-Iglesias, Peter Caravan, David Esteban-Gómez.ACS Applied Materials & Interfaces 2022, 14 Molecular Parameters Promoting High Relaxivity in Cluster–Nanocarrier Magnetic Resonance Imaging Contrast Agents. André Ohlin, Rudi van Eldik, Olga Rodriguez, Christopher Albanese, Edward Van Keuren, Sarah L. Trevor Lyons, Chloe Kekedjian, Priscilla Glaser, C.Journal of the American Chemical Society 2022, 144 Mn2+ Bispidine Complex Combining Exceptional Stability, Inertness, and MRI Efficiency. Daouda Ndiaye, Patrick Cieslik, Hubert Wadepohl, Agnès Pallier, Sandra Même, Peter Comba, Éva Tóth.This article is cited by 73 publications. The possibility of extending this technique to other metal ions such as Gd(III) is discussed. For example, Mn(II) binds to the multimetal binding site A on human serum albumin with two inner-sphere water ligands that undergo rapid exchange (1.06 × 10 8 s –1 at 37 ☌). We show that the technique can be extended to metalloproteins or complex:protein interactions. The hydration number can be obtained for micromolar Mn(II) concentrations. The method can be implemented on commercial NMR spectrometers working at fields of 7 T and higher. Using a combination of literature data and experimental data for 12 Mn(II) complexes, we show that this method provides accurate estimates of q with an uncertainty of ☐.2 water molecules. It is demonstrated that the maximum 17O relaxivity is directly proportional to the number of inner-sphere water ligands ( q). The line width of bulk H 2 17O is measured in the presence and absence of Mn(II) as a function of temperature, and transverse 17O relaxivities are calculated.
Here we describe a simple method to estimate the inner-sphere hydration state of the Mn(II) ion in coordination complexes and metalloproteins.
0 kommentar(er)
